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Endocrine Abstracts

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ea0050oc3.5 | Obesity, Diabetes Thyroid | SFEBES2017

Increased global long interspersed nucleotide element 1 DNA methylation in type 2 diabetes mellitus individuals relates to lower blood pressure and BMI

Malipatil Nagaraj , Siddals Kirk , Moreno Gabriela , Narayanan Ram , Donn Rachelle , Lunt Mark , Heald Adrian H , Gibson J Martin

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...
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ea0050oc3.5 | Obesity, Diabetes Thyroid | SFEBES2017

Increased global long interspersed nucleotide element 1 DNA methylation in type 2 diabetes mellitus individuals relates to lower blood pressure and BMI

Malipatil Nagaraj , Siddals Kirk , Moreno Gabriela , Narayanan Ram , Donn Rachelle , Lunt Mark , Heald Adrian H , Gibson J Martin

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...
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ea0065p190 | Metabolism and Obesity | SFEBES2019

Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes – a 14-year follow up study

Heald Adrian , Yadegarfar Ghasem , Livingston Mark , Fachim Helene , Lunt Mark , Narayanan Ram Prakash , Siddals Kirk , Cortes Gabriela , Hackett Geoff , Naseem Asma , Kochhar Rupinder , Inamullah Khan , Donn Rachelle , Gibson Martin , Jones Hugh

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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